Micky van de Ven Brace Ends The Toffees' Unbeaten Streak at New Home Ground
The Dutch defender emerged as the first defender to score twice in a Premier League game for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads home twice in opening period
Everton's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets third in dying moments
This loss is Everton's initial at their new ground
The Tottenham defender found the net twice as Tottenham extended their unbeaten run in away games in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after 133 years at the end of the previous campaign.
But Spurs captain Van de Ven pounced on two occasions from corners in the first half to put their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien believed he had levelled the tally a short while after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
Beto, in the meantime, failed to convert a number of chances, while Vicario made a series of fine saves to guarantee Tottenham went five matches on the road without defeat in the English top flight.
But the VAR stepped in, advising Craig Pawson to review the goal on the pitchside monitor and the referee ruled that the winger and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
This victory moves Thomas Frank's team up to third in the division, a handful of points off north London rivals and leaders the Gunners.
The Merseyside club remain in 14th position and sit six points clear of the drop zone.
Tottenham analysis: The defender excels in duties at both ends of the field
After a uninspiring weekday display in the European competition against the French side, where they mustered a only attempts on goal, Frank opted for Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The summer signing was failed to make much of an impact before being substituted for the substitute after an hour on the pitch, but it turns out he proved unnecessary in the final outcome.
Centre-back the Dutchman transformed into an attacking force to be reckoned with.
Spurs' first goal came from a well-worked corner routine, with Rodrigo Bentancur heading the ball toward the six-yard box for an free Van de Ven to score.
And the captain - filling in as skipper in the Argentine's unavailability - notched his second in added time as he outjumped the England keeper to nod in.
Van de Ven was just as impressive in defence, combining well with his defensive colleague as the pair handled superbly with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Toffees lacking finishing touch
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off somewhat and supporters headed to the exits after Sarr's third for Tottenham.
The end in the team's winning streak at home won't be a major worry for David Moyes, but their attacking woes are.
Beto and the other striker - the Toffees' pair of recognised centre-forwards - had scored only one league goal between them before the weekend's match.
And they were failed to contribute to that miserable tally on a damp and dreary night on Merseyside.
The striker's performance was summed up when he chose to bicycle-kick a clear chance from near the goal, even with having space and opportunity to readjust for a more conventional attempt that would have challenged Vicario.
Barry, as well, failed to make an impact after coming on for Beto in the second half.
It was not for a shortage of opportunity. Most of the home side's attacks came through the winger and Ndiaye, who tirelessly delivered threatening balls into the Spurs penalty area.
What next for both teams?
Everton: Moyes' men travel to Sunderland in the top flight on early November at 20:00 GMT.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their fourth-round League Cup tie against the Magpies.